Enhanced Gametocyte Formation in Young Erythrocytes byPlasmodium falciparumIn Vitro
- 1 May 1992
- journal article
- Published by Wiley in The Journal of Protozoology
- Vol. 39 (3), 429-432
- https://doi.org/10.1111/j.1550-7408.1992.tb01476.x
Abstract
Two gametocyte-forming clones, HB-3 and 3D7, were used. Concentrates of late stage parasites were mixed with bloods containing different proportions of young erythrocytes, and the parasitemia and proportion of gametocytes determined after 2, 3 or 4 days of culture. Significantly more gametocytes were formed in light cells than in heavy cells separated from the same normal blood samples. Up to seven times more gametocytes were formed in reticulocyte-rich bloods from patients with sickle cell anemia than in normal control blood.Keywords
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