The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy
- 10 December 2012
- journal article
- research article
- Published by Wiley in Pediatric Transplantation
- Vol. 17 (2), 133-143
- https://doi.org/10.1111/petr.12022
Abstract
RVIs are a significant cause of morbidity and mortality in immunocompromised children. We analyzed the characteristics and outcomes of infection by four respiratory viruses (RSV, adenovirus, influenza, and parainfluenza) treated at a pediatric tertiary care hospital in a retrospective cohort of patients who had received cancer chemotherapy, hematopoietic stem cell, or SOT. A total of 208 infections were studied among 166 unique patients over a time period of 1993-2006 for transplant recipients, and 2000-2005 for patients with cancer. RSV was the most common respiratory virus identified. There were 17 (10% of all patients) deaths overall, of which 12 were at least partly attributed to the presence of a RVI. In multivariate models, LRT symptoms in the absence of upper respiratory symptoms on presentation (OR 10.2 [2.3, 45.7], p = 0.002) and adenoviral infection (OR 3.7 [1.1, 12.6], p = 0.034) were significantly associated with poor outcome, defined as death or disability related to RVI. All of the deaths occurred in patients who had received either solid organ or HSCT. There were no infections resulting in death or disability in the cancer chemotherapy group.Keywords
This publication has 18 references indexed in Scilit:
- Symptomatic Parainfluenza Virus Infections in Children Undergoing Hematopoietic Stem Cell TransplantationTransplantation and Cellular Therapy, 2011
- Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipientsCurrent Opinion in Infectious Diseases, 2011
- Long-term impact of respiratory viral infection after pediatric lung transplantationPediatric Transplantation, 2010
- Respiratory viral infections within one year after pediatric lung transplantTransplant Infectious Disease, 2009
- The challenge of respiratory virus infections in hematopoietic cell transplant recipientsBritish Journal of Haematology, 2008
- Respiratory syncytial virus infections in children with acute myeloid leukemia: A report from the Children's Oncology GroupPediatric Blood & Cancer, 2008
- Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic AdvancesClinical Microbiology Reviews, 2008
- Risk Factors for Severe Respiratory Syncytial Virus Disease in Children With Cancer: The Importance of Lymphopenia and Young AgePublished by American Academy of Pediatrics (AAP) ,2008
- Emerging Infections: Adenovirus Infections in Transplant RecipientsClinical Infectious Diseases, 2006
- Respiratory Syncytial Viral Infection in Children with Compromised Immune FunctionNew England Journal of Medicine, 1986