Iridium-Catalyzed Reduction of Secondary Amides to Secondary Amines and Imines by Diethylsilane
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- 6 July 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (28), 11304-11307
- https://doi.org/10.1021/ja304547s
Abstract
Catalytic reduction of secondary amides to imines and secondary amines has been achieved using readily available iridium catalysts such as [Ir(COE)2Cl]2 with diethylsilane as reductant. The stepwise reduction to secondary amine proceeds through an imine intermediate that can be isolated when only 2 equiv of silane is used. This system requires low catalyst loading and shows high efficiency (up to 1000 turnovers at room temperature with 99% conversion have been attained) and an appreciable level of functional group tolerance.This publication has 32 references indexed in Scilit:
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