Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging
Top Cited Papers
Open Access
- 14 November 2011
- journal article
- review article
- Published by Hindawi Limited in Journal of Signal Transduction
- Vol. 2012, 1-17
- https://doi.org/10.1155/2012/329635
Abstract
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as “redox messengers” in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.Keywords
This publication has 211 references indexed in Scilit:
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signalingTrends in Biochemical Sciences, 2010
- Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomesTrends in Biochemical Sciences, 2010
- Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truthFree Radical Biology & Medicine, 2010
- PGC-1α in aging and anti-aging interventionsBiochimica et Biophysica Acta (BBA) - General Subjects, 2009
- HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurementsFree Radical Biology & Medicine, 2009
- Mitochondrial biogenesis and healthy agingExperimental Gerontology, 2008
- An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegansCurrent Biology, 2007
- Selective degradation of mitochondria by mitophagyArchives of Biochemistry and Biophysics, 2007
- The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesisApoptosis, 2007
- The mitochondrial permeability transitionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1995