Peroxisome Proliferator-Activated Receptor Alpha Target Genes
Top Cited Papers
Open Access
- 26 September 2010
- journal article
- research article
- Published by Hindawi Limited in PPAR Research
- Vol. 2010, 1-20
- https://doi.org/10.1155/2010/612089
Abstract
The peroxisome proliferator-activated receptor alpha (PPAR) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. PPARserves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPARbinds and is activated by numerous fatty acids and fatty acid-derived compounds. PPARgoverns biological processes by altering the expression of a large number of target genes. Accordingly, the specific role of PPARis directly related to the biological function of its target genes. Here, we present an overview of the involvement of PPARin lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARtarget genes. The emphasis is on gene regulation by PPARin liver although many of the results likely apply to other organs and tissues as well.
Keywords
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