How do ABC transporters drive transport?
- 1 October 2004
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 385 (10), 927-933
- https://doi.org/10.1515/bc.2004.121
Abstract
Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive transport. In the last two decades these proteins have been extensively characterized on a genetic and biochemical level, and in recent years high-resolution crystal structures of several nucleotide-binding domains and full-length transporters have extended our knowledge. Here we discuss the possible mechanisms of transport that have been derived from these crystal structures and the extensive available biochemical data.Keywords
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