Intercellular transfer of cell-surface proteins is common and can affect many stages of an immune response
- 9 February 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 7 (3), 238-243
- https://doi.org/10.1038/nri2020
Abstract
Cells can extend the limits of their transcriptome by using proteins captured from other cells. Through an exchange of specific proteins, tools and information can be shared to establish integrated communities of cells that are better able to coordinate stages of an immune response. Transferred proteins can also contribute to pathology by allowing, for example, infection of cell types not otherwise infected. Here, I present the case for considering the intercellular transfer of cell-surface proteins between immune cells as commonplace and important.Keywords
This publication has 75 references indexed in Scilit:
- Automated detection of tunneling nanotubes in 3D imagesCytometry Part A, 2006
- Infectious tumour cellsNature, 2006
- Clonal Origin and Evolution of a Transmissible CancerCell, 2006
- Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic functionProceedings of the National Academy of Sciences of the United States of America, 2006
- Agonist/endogenous peptide–MHC heterodimers drive T cell activation and sensitivityNature, 2005
- Nanotubular Highways for Intercellular Organelle TransportScience, 2004
- Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion?Blood, 2003
- Active trans-synaptic capture of membrane fragments by natural killer cellsEuropean Journal of Immunology, 2002
- Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune SynapsesThe Journal of Experimental Medicine, 2001
- TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T CellsScience, 1999