Modulation of Sheep Erythrocyte Receptor Expression by Anti‐CD4, Anti‐CD8, and Anti‐HLA Antibodies
- 1 February 1988
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 27 (2), 181-185
- https://doi.org/10.1111/j.1365-3083.1988.tb02337.x
Abstract
The modulation of E receptors on T cells by anti-CD4 and/or anti-CD8 is reported. The percentage of E rosette-forming cells (RFC) was decreased when sheep erythrocyte and mononuclear cells were incubated in the presence of monoclonal antibodies anti-CD4 and/or anti-CD8. This inhibition was not due to shedding of the E receptor and it was reversed by 8-Br.-3',5' cyclic guanosine monophosphate (cGMP). In contrast, anti-HLA antibodies induced an enhancement of sheep erythrocyte receptor expression evaluated by RFC.Keywords
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