Do electromagnetic fields enhance the effects of environmental carcinogens?
- 15 October 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Radiation Protection Dosimetry
- Vol. 132 (2), 228-231
- https://doi.org/10.1093/rpd/ncn258
Abstract
Epidemiological studies have reported an increased risk of leukaemia in children who are exposed to extremely low-frequency (ELF) magnetic fields (MF), suggesting that ELF MFs may be carcinogenic to humans. No carcinogenic effects have been found in animal studies that have tested ELF MFs alone. Similarly, genotoxicity studies have generally not shown effects from MFs alone. However, ELF MFs have been reported to enhance the effects of known carcinogenic or mutagenic agents in a few animal studies and in several in vitro studies. This paper discusses the findings of studies on such combined effects. The majority of in vitro studies have reported positive findings, which supports the conclusion that MFs of 100 µT or higher interact with other chemical and physical agents. Further studies should address biophysical mechanisms and dose–response relationship below 100 µT. Animal studies designed according to the classical initiation–promotion concept may not be sufficient for studying the cocarcinogenic effects of MFs, and further studies using novel study designs would be useful. Epidemiological data on the interaction between MFs and other environmental agents are scant and inconclusive, and any further studies may be difficult because of the scarcity of subjects with suitable combined exposures.Keywords
This publication has 17 references indexed in Scilit:
- Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studiesInternational Journal of Radiation Biology, 2006
- Arc and resistance welding and tumours of the endocrine glands: a Swedish case-control study with focus on extremely low frequency magnetic fieldsOccupational and Environmental Medicine, 2005
- Effects of 50Hz magnetic fields on cancer induced by ionizing radiation in miceInternational Journal of Radiation Biology, 2001
- The effects of weak magnetic fields on radical recombination reactions in micellesInternational Journal of Radiation Biology, 2000
- Effect of 26 week magnetic field exposures in a DMBA initiation–promotion mammary gland model in Sprague–Dawley ratsCarcinogenesis: Integrative Cancer Research, 1999
- Effects of weak magnetic fields on free radical recombination reactionsMolecular Physics, 1998
- Cell Proliferation in the Evaluation of Carcinogenic Risk and the Inadequacies of the Initiation-Promotion ModelInternational Journal of Toxicology, 1998
- ACCELERATION OF MAMMARY TUMORIGENESIS BY EXPOSURE OF 7,12-DIMETHYLBENZ\[a]ANTHRACENE-TREATED FEMALE RATS IN A 50-Hz, 100-muT MAGNETIC FIELD: REPLICATION STUDYJournal of Toxicology and Environmental Health, Part A, 1998
- Exposure of DMBA-treated female rats in a 50-Hz, 50 μTesla magnetic field: effects on mammary tumor growth, melatonin levels, and T lymphocyte activationCarcinogenesis: Integrative Cancer Research, 1996
- Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic fieldCancer Letters, 1993