CSF‐1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF‐1 receptor
Open Access
- 29 October 2007
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 581 (28), 5377-5381
- https://doi.org/10.1016/j.febslet.2007.10.031
Abstract
The CSF‐1 receptor is a protein‐tyrosine kinase that has been shown to undergo regulated intramembrane proteolysis, or RIPping. Here, we have compared receptor downregulation and RIPping in response to CSF‐1 and TPA. Our studies show that CSF‐1 is a relatively poor inducer of RIPping and that CSF‐1‐induced receptor downregulation is largely independent of RIPping. TPA is a strong inducer of RIPping and TPA‐induced receptor downregulation is mediated by RIPping. We further found that RIPping is dependent on TACE or a TACE‐like protease, that CSF‐1 and TPA use independent pathways to initiate RIPping, and that the intracellular domain is targeted for degradation through ubiquitination.Keywords
This publication has 29 references indexed in Scilit:
- The Macrophage at the Crossroads of Insulin Resistance and AtherosclerosisCirculation Research, 2007
- The interface between innate and adaptive immunityNature Immunology, 2004
- Purification and Identification of Protein-Tyrosine Kinase-binding Proteins Using Synthetic Phosphopeptides as Affinity ReagentsMolecular & Cellular Proteomics, 2004
- Phorbol 12-Myristate 13-Acetate-Induced Release of the Colony-Stimulating Factor 1 Receptor Cytoplasmic Domain into the Cytosol Involves Two Separate Cleavage EventsMolecular and Cellular Biology, 2004
- NOTCH ANDPRESENILIN: Regulated Intramembrane Proteolysis Links Development and DegenerationAnnual Review of Neuroscience, 2003
- The ADAMs family of metalloproteases: multidomain proteins with multiple functionsGenes & Development, 2003
- γ-Secretase-mediated proteolysis in cell-surface-receptor signallingNature Reviews Molecular Cell Biology, 2002
- C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminusOncogene, 2002
- Regulated Intramembrane ProteolysisCell, 2000
- The Product of the c- fms Proto-Oncogene: a Glycoprotein with Associated Tyrosine Kinase ActivityScience, 1985