A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor
Open Access
- 1 March 2001
- journal article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 276 (12), 8856-8864
- https://doi.org/10.1074/jbc.m006966200
Abstract
No abstract availableKeywords
This publication has 41 references indexed in Scilit:
- Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth FactorPublished by Elsevier BV ,2000
- Protein Kinase C-ζ and Phosphoinositide-dependent Protein Kinase-1 Are Required for Insulin-induced Activation of ERK in Rat AdipocytesPublished by Elsevier BV ,1999
- Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPKScience, 1998
- Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1Science, 1998
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesisNature, 1996
- A Grb2-associated docking protein in EGF- and insulin-receptor signallingNature, 1996
- Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cellsFEBS Letters, 1995
- How receptors turn Ras onNature, 1993
- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transductionCell, 1992