The Immunological Synapse--a Multitasking System
- 22 February 2002
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5559), 1479-1480
- https://doi.org/10.1126/science.1069896
Abstract
The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings ( Lee et al.) demonstrating that T cell receptor signaling takes place well before formation of the immunological synapse, suggesting that this dynamic structure may have other functions.Keywords
This publication has 10 references indexed in Scilit:
- T Cell Receptor Signaling Precedes Immunological Synapse FormationScience, 2002
- The immunological synapse and CD28-CD80 interactionsNature Immunology, 2001
- The Immunological Synapse of CTL Contains a Secretory Domain and Membrane BridgesImmunity, 2001
- The immunological synapse: required for T cell receptor signalling or directing T cell effector function?Current Biology, 2001
- TCR-Induced Transmembrane Signaling by Peptide/MHC Class II Via Associated Ig-α/β DimersScience, 2001
- Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognitionSeminars in Immunology, 2000
- The Immunological Synapse: A Molecular Machine Controlling T Cell ActivationScience, 1999
- Three-dimensional segregation of supramolecular activation clusters in T cellsNature, 1998
- Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR EngagementImmunity, 1996
- Lymphocyte responses and cytokinesCell, 1994