Effects of chronic nitric oxide synthase inhibition on cerebral arterioles in Wistar???Kyoto rats
- 1 March 2004
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Hypertension
- Vol. 22 (3), 529-534
- https://doi.org/10.1097/00004872-200403000-00015
Abstract
Cerebral arterioles in stroke-prone spontaneously hypertensive rats (SHRSP), but not in Sprague–Dawley rats with hypertension induced by nitric oxide (NO) synthase inhibition, undergo inward remodeling. The goal of this study was to determine whether development of vascular inward remodeling may depend on genetic factors. We examined effects of NO synthase inhibition on the structure of cerebral arterioles in Wistar–Kyoto rats (WKY), a rat strain genetically distinct from Sprague–Dawley. Pressure (servonull), diameter (cranial window) and cross-sectional area of the vessel wall (CSA, histologically) were measured in maximally dilated (EDTA) cerebral arterioles in WKY, untreated (n = 8) or treated for 3 months with the NO synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME) (10 mg/kg per day, n = 10) in the drinking water, and in untreated SHRSP (n = 7). Treatment with l-NAME in WKY increased mean cerebral arteriolar pressure (69 ± 7 versus 47 ± 7 mmHg, P 0.05) and pulse pressure (30 ± 3 versus 17 ± 1 mmHg, P 0.05) to levels significantly lower than in SHRSP (98 ± 5 and 35 ± 1 mmHg respectively, P 0.05). CSA was significantly greater in l-NAME-treated WKY and SHRSP than in untreated WKY (1692 ± 50 and 1525 ± 98 μm2 respectively, versus 1224 ± 85, P 0.05). External diameter was significantly less in l-NAME-treated WKY than in untreated WKY (119 ± 5 versus 135 ± 4 μm, P 0.05) but significantly greater than in SHRSP (98 ± 1 μm, P 0.05).ConclusionCerebral arterioles undergo hypertrophy and remodeling in WKY with l-NAME-induced hypertension. These findings suggest that genetic factors present in WKY and SHRSP may play a role in the development of vascular inward remodeling during chronic hypertension in rats. Cerebral arterioles undergo hypertrophy and remodeling in WKY with l-NAME-induced hypertension. These findings suggest that genetic factors present in WKY and SHRSP may play a role in the development of vascular inward remodeling during chronic hypertension in rats.This publication has 28 references indexed in Scilit:
- Effects of an Angiotensin-Converting Enzyme Inhibitor and a β-Blocker on Cerebral Arterioles in RatsHypertension, 1999
- Effects of Chronic Nitric Oxide Synthase Inhibition on Cerebral Arterioles in RatsHypertension, 1997
- Effects of Endothelin Receptor Inhibition on Cerebral Arterioles in Hypertensive RatsHypertension, 1996
- Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy.Hypertension, 1994
- Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats.Hypertension, 1993
- Remodeling of cerebral arterioles in chronic hypertension.Hypertension, 1989
- Effects of acute and chronic cilazapril treatment in spontaneously hypertensive rats.British Journal of Clinical Pharmacology, 1989
- Mechanics of cerebral arterioles in hypertensive rats.Circulation Research, 1988
- Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats.Hypertension, 1984
- The Hemodynamic Consequences of Regional Hypotension in Spontaneously Hypertensive and Normotensive RatsActa Physiologica Scandinavica, 1971