Drug-Related Hepatotoxicity
Top Cited Papers
- 16 February 2006
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 354 (7), 731-739
- https://doi.org/10.1056/nejmra052270
Abstract
Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients are exposed, toxic effects that are very infrequent may emerge. This review explains the difficulties in identifying the cause of hepatotoxic effects in such situations and provides clinical guidance with regard to the detection, evaluation, and possible prevention of drug-related hepatotoxicity.Keywords
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