Lactoferrin and other markers from gingival crevicular fluid and saliva before and after periodontal treatment
- 17 May 2004
- journal article
- research article
- Published by Wiley in Journal of Clinical Periodontology
- Vol. 31 (7), 511-514
- https://doi.org/10.1111/j.1600-051x.2004.00512.x
Abstract
The aim of the study was to verify (i) if crevicular fluid defence variables reflect the changes after surgical periodontal treatment and (ii) if they are in correspondence with changes of these variables in the unstimulated and stimulated whole saliva. For 12 male and 13 female volunteers with chronic periodontitis lactoferrin concentration as well as the lysozyme and peroxidase activities were determined in crevicular fluid as well as in unstimulated and stimulated saliva before and 14 days after surgical periodontal treatment by a minimal invasive flap technique. The lactoferrin concentrations decreased significantly in the crevicular fluid eluting solution from 1.63 to 1.23 mg/l reflecting a decrease in the total amount collected, in unstimulated saliva from 10.54 to 8.96 mg/l, and in stimulated saliva from 9.00 to 7.11 mg/l after treatment. No significant change could be found for lysozyme. Peroxidase activity was significantly reduced from 269.06 to 186.15 U/l only in the crevicular fluid. The results of this study suggest that (i) the defence factor lactoferrin is suitable for monitoring of periodontal treatment results and (ii) changes of the lactoferrin concentration in crevicular fluid are related with significant changes in unstimulated and stimulated saliva.Keywords
This publication has 24 references indexed in Scilit:
- Relationship of changes in interleukin‐8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens followingnon‐surgical periodontal therapy in subjects with chronic periodontitisJournal of Clinical Periodontology, 2002
- Lactoferrin Iron Levels Affect Attachment ofActinobacillus actinomycetemcomitansto Buccal Epithelial CellsThe Journal of Periodontology, 2002
- Lactoferrin Iron Levels Are Reduced in Saliva of Patients With Localized Aggressive PeriodontitisThe Journal of Periodontology, 2002
- Salivary lactoferrin and low‐Mr mucin MG2 in Actinobacillus actinomycetemcomitans‐associated periodontitisJournal of Clinical Periodontology, 1999
- Detection of stable and active periodontitis sites by clinical assessment and gingival crevicular acute‐phase protein levelsJournal of Periodontal Research, 1996
- Lactoferrin in the gingival crevice as a marker of polymorphonuclear leucocytes in periodontal diseasesJournal of Clinical Periodontology, 1993
- Crevicular fluid myeloperoxidase at healthy, gingivitis and periodontitis sitesJournal of Clinical Periodontology, 1989
- Antimicrobial Factors in Saliva: Ontogeny and Relation to Oral HealthJournal of Dental Research, 1987
- Enzyme activity in human gingival crevicular fluid: considerations in data reporting based on analysis of individual crevicular sitesJournal of Clinical Periodontology, 1986
- Lysozyme and Lactoferrin Quantitation in the Crevicular FluidThe Journal of Periodontology, 1983