Bile Acid Pools, Kinetics and Biliary Lipid Composition before and after Cholecystectomy
- 6 December 1973
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 289 (23), 1213-1216
- https://doi.org/10.1056/nejm197312062892302
Abstract
Bile acid pools, kinetics and biliary lipid composition were determined in 10 patients with cholesterol gallstones before and after cholecystectomy. The determinations of post-cholecystectomy bile acid pools were carried out three to 41 months after surgery. Cholecystectomy had no significant effect on biliary lipid composition, and the bile remained lithogenic after removal of the gallbladder. The total bile acid pool in the patients was small before cholecystectomy (about 1.0 g), and there was no significant change in bile acid pool size after removal of the gallbladder. Cholic and chenodeoxycholic acid synthesis did not change after cholecystectomy. The fractional daily turnover rate of cholic and chenodeoxycholic acid was significantly greater after cholecystectomy. These findings support the view that the gallbladder does not have an important role either in the formation of lithogenic bile or in the reduction of bile acid pool size observed in patients with cholesterol gallstones. (N Engl J Med 289:1213–1216, 1973)Keywords
This publication has 21 references indexed in Scilit:
- Bile Composition at and after Surgery in Normal Persons and Patients with GallstonesNew England Journal of Medicine, 1972
- Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol GallstonesJCI Insight, 1972
- Bile composition, bile salt metabolism and gallstonesArchives of Internal Medicine, 1972
- Alterations in Hepatic Bile Composition After CholecystectomyGastroenterology, 1972
- Bile Acid Metabolism in Patients with CirrhosisGastroenterology, 1972
- Relationship of Bile Acid Pool Size to Biliary Lipid Excretion and the Formation of Litho Genic Bile in ManGastroenterology, 1971
- Relationship between the Biliary Excretion of Bile Acids and the Excretion of Water, Lecithin, and Cholesterol in ManEuropean Journal of Clinical Investigation, 1971
- Source of Abnormal Bile in Patients with Cholesterol GallstonesNew England Journal of Medicine, 1970
- The physicochemical basis of cholesterol gallstone formation in manJCI Insight, 1968
- The Turnover of Cholic Acid in Man.* Bile Acids and Steroids 51.Acta Physiologica Scandinavica, 1957