Inflammation and vascular endothelial activation in an Aboriginal population: relationships to coronary disease risk factors and nutritional markers
- 19 May 2003
- journal article
- indigenous health
- Published by AMPCo in The Medical Journal of Australia
- Vol. 178 (10), 495-500
- https://doi.org/10.5694/j.1326-5377.2003.tb05324.x
Abstract
Objective: To describe the levels of inflammation and vascular endothelial activation in an Aboriginal community, and the relationship of these factors to coronary heart disease (CHD) risk factors and markers of nutritional quality. Design and participants: A cross‐sectional survey of 95 women and 76 men participating in a chronic‐disease prevention program. Setting: A remote Aboriginal community in Western Australia in 1996. Main outcome measures: Concentrations of markers of inflammation (C‐reactive protein [CRP]) and vascular endothelial activation (soluble E‐selectin [sE‐selectin]); presence of metabolic syndrome; concentrations of diet‐derived antioxidants. Results: Participants exhibited very high plasma concentrations of CRP (mean, 5.4 mg/L; 95% CI, 4.6–6.3 mg/L) and sE‐selectin (mean, 119 ng/mL; 95% CI, 111–128 ng/mL). Both CRP and sE‐selectin concentrations were significantly higher in the presence of the metabolic syndrome. There were significant inverse linear relationships between concentrations of CRP and plasma concentrations of the antioxidants lycopene, β‐carotene, cryptoxanthin and retinol. Even stronger inverse associations were evident between concentrations of sE‐selectin and lycopene, β‐carotene, cryptoxanthin and lutein. Conclusions: Vascular inflammation and endothelial activation may be important mediators of elevated CHD risk in Aboriginal people. Inadequate nutrition and physical inactivity may contribute to this process.Keywords
This publication has 27 references indexed in Scilit:
- Dietary modulation of endothelial function: implications for cardiovascular diseaseThe American Journal of Clinical Nutrition, 2001
- Albuminuria in Australian Aboriginal people: prevalence and associations with components of the metabolic syndromeDiabetologia, 2000
- Increase in prevalence of obesity and diabetes and decrease in plasma cholesterol in a central Australian Aboriginal communityThe Medical Journal of Australia, 2000
- Aboriginal deaths in Western Australia: 1985-89 and 1990-94Australian and New Zealand Journal of Public Health, 2000
- C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in WomenNew England Journal of Medicine, 2000
- Stability of individual carotenoids, retinol and tocopherols in human plasma during exposure to light and after extractionJournal of Chromatography B: Biomedical Sciences and Applications, 1999
- Atherosclerosis — An Inflammatory DiseaseNew England Journal of Medicine, 1999
- Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease CasesCirculation, 1997
- Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNew England Journal of Medicine, 1997
- Apparent dietary intake in remote Aboriginal communitiesAustralian Journal of Public Health, 1994