HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
Open Access
- 15 August 2005
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (16), 10218-10225
- https://doi.org/10.1128/jvi.79.16.10218-10225.2005
Abstract
Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL) play in controlling HIV infection. HLA-B63, the serological marker for the closely related HLA-B*1516 and HLA-B*1517 alleles, shares the epitope binding motif of HLA-B57 and HLA-B58, two alleles that have been associated with slow HIV disease progression. We investigated whether HIV-infected individuals who express HLA-B63 generate CTL responses that are comparable in breadth and specificity to those of HLA-B57/58-positive subjects and whether HLA-B63-positive individuals would also present with lower viral set points than the general population. The data show that HLA-B63-positive individuals indeed mounted responses to previously identified HLA-B57-restricted epitopes as well as towards novel, HLA-B63-restricted CTL targets that, in turn, can be presented by HLA-B57 and HLA-B58. HLA-B63-positive subjects generated these responses early in acute HIV infection and were able to control HIV replication in the absence of antiretroviral treatment with a median viral load of 3,280 RNA copies/ml. The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection.Keywords
This publication has 32 references indexed in Scilit:
- T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV InfectionImmunity, 2004
- High responsiveness of HLA‐B57‐restricted Gag‐specific CD8+ T cells in vitro may contribute to the protective effect of HLA‐B57 in HIV‐infectionEuropean Journal of Immunology, 2004
- Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 InfectionJournal of Virology, 2004
- Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 InfectionThe Journal of Experimental Medicine, 2004
- Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple EthnicitiesJournal of Virology, 2004
- Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infectionAIDS, 2003
- Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune DefenseScience, 2002
- Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in PlasmaScience, 1996
- Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolutionJournal of Molecular Biology, 1991
- Specificity pockets for the side chains of peptide antigens in HLA-Aw68Nature, 1989