Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging
Open Access
- 17 February 2014
- journal article
- other
- Published by Elsevier BV in Cell Reports
- Vol. 6 (4), 608-616
- https://doi.org/10.1016/j.celrep.2014.01.015
Abstract
• dfoxo/daf-16 is not required beyond gut/adipose tissue to counteract aging • Neuroendcrine dFOXO extends lifespan independently of dfoxo in other cell types • In contrast, gut/adipose dFOXO requires dfoxo in other tissues to alter metabolismFunding Information
- Wellcome Trust
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering
- National Institutes of Health (P40 OD010440)
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