Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training
- 20 October 2006
- journal article
- research article
- Published by Wiley in Aging Cell
- Vol. 5 (6), 495-503
- https://doi.org/10.1111/j.1474-9726.2006.00242.x
Abstract
The number of hematopoietic stem cells (HSC) and endothelial progenitor cells (EPC) is thought to be a marker for neovascularization and vascular repair. Because physical inactivity and aging are risk factors for cardiovascular diseases, these factors may influence the numbers of HSCs and EPCs. Therefore, we examined baseline and exercise-induced levels of HSCs and EPCs in sedentary and trained young and older men. To study the role of aging in eight sedentary young (19-28 years) and eight sedentary older men (67-76 years), baseline and acute exercise-induced numbers of HSCs (CD34+-cells) and EPCs (CD34+/VEGFR-2+-cells) were quantified by fluorescence-activated cell sorter (FACS) analysis. To examine the effect of chronic training, eight age-matched trained young men (18-28 years) were compared with sedentary young men, whereas older men performed an 8-week endurance training. Older men showed significantly lower baseline and exercise-induced levels of HSCs/EPCs than the young men (P < 0.05). In young and older men, acute exercise significantly increased HSCs (P < 0.01), but not EPCs. The absolute increase in numbers of HSCs was attenuated in older men (P = 0.03). Apart from the lower baseline numbers of EPCs after chronic training in older men, training status did not alter baseline or exercise-induced levels of HSCs/EPCs in young and older men. We concluded that advancing age results in lower circulating numbers of HSCs and EPCs and attenuates the acute exercise-induced increase in HSCs. Interestingly, in young as well as in older men chronic endurance training does not affect baseline and exercise-induced numbers of HSCs and EPCs.Keywords
This publication has 40 references indexed in Scilit:
- Flow cytometric measurement of circulating endothelial cells: The effect of age and peripheral arterial disease on baseline levels of mature and progenitor populationsCytometry Part B: Clinical Cytometry, 2006
- Lower skeletal muscle capillarization and VEGF expression in aged vs. young menJournal of Applied Physiology, 2006
- Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor Cells in Patients With Ischemic SyndromesCirculation, 2005
- Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular EventsCirculation, 2005
- Impaired Progenitor Cell Activity in Age-Related Endothelial DysfunctionJournal of the American College of Cardiology, 2005
- Nitric oxide differentially regulates proliferation and mobilization of endothelial progenitor cells but not of hematopoietic stem cellsThrombosis and Haemostasis, 2005
- Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cellsBiochemical and Biophysical Research Communications, 2004
- Angiogenic growth factor response to acute systemic exercise in human skeletal muscleJournal of Applied Physiology, 2004
- Aging, Progenitor Cell Exhaustion, and AtherosclerosisCirculation, 2003
- Physical Activity, All-Cause Mortality, and Longevity of College AlumniThe New England Journal of Medicine, 1986