Regulation of cell adhesion by PAI‐1
- 1 March 1999
- Vol. 107 (1-6), 54-61
- https://doi.org/10.1111/j.1699-0463.1999.tb01526.x
Abstract
Type I plasminogen activator inhibitor (PAI‐1) is the primary inhibitor of tissue‐and urokinase‐type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI‐1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI‐1 binding site and the specific site for urokinase plasminogen activator receptor (uPAR). PAI‐1 is able to regulate uPAR‐mediated cell adhesion by competing with uPAR for VN binding. Binding of PAI‐1 to SMD may also affect integrin‐mediated cell adhesion to VN by hindering integrin binding to the RGD sequence adjacent to the uPAR binding site.Keywords
This publication has 53 references indexed in Scilit:
- Identification of a PAI-1 binding site in vitronectinBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994
- Synthetic peptides derived from the sequence around the plasmin cleavage site in vitronectinFEBS Letters, 1993
- Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptideBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
- Structural basis of latency in plasminogen activator inhibitor-1Nature, 1992
- Plasmin cleavage of vitronectin Identification of the site and consequent attenuation in binding plasminogen activator inhibitor‐1FEBS Letters, 1991
- Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectinBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
- Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor.The Journal of cell biology, 1990
- Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasmaFEBS Letters, 1988
- Somatomedin B: Mitogenic Activity Derived from Contaminant Epidermal Growth FactorScience, 1981
- Isolation and characterization of polypeptides from human plasma enhancing the growth of human normal cells in cultureBiochemical and Biophysical Research Communications, 1974