Automated Analysis of Background EEG and Reactivity During Therapeutic Hypothermia in Comatose Patients After Cardiac Arrest
- 22 January 2014
- journal article
- research article
- Published by SAGE Publications in Clinical Eeg and Neuroscience
- Vol. 45 (1), 6-13
- https://doi.org/10.1177/1550059413509616
Abstract
Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypothermia provides important outcome information, but is time-consuming and not always consistent between reviewers. Automated EEG analysis may help quantify the brain damage. Forty-six comatose patients in therapeutic hypothermia, after cardiac arrest, were included in the study. EEG background was quantified with burst-suppression ratio (BSR) and approximate entropy, both used to monitor anesthesia. Reactivity was detected through change in the power spectrum of signal before and after stimulation. Automatic results obtained almost perfect agreement (discontinuity) to substantial agreement (background reactivity) with a visual score from EEG-certified neurologists. Burst-suppression ratio was more suited to distinguish continuous EEG background from burst-suppression than approximate entropy in this specific population. Automatic EEG background and reactivity measures were significantly related to good and poor outcome. We conclude that quantitative EEG measurements can provide promising information regarding current state of the patient and clinical outcome, but further work is needed before routine application in a clinical setting.Keywords
This publication has 29 references indexed in Scilit:
- Predict recovery of consciousness in post-acute severe brain injury: The role of EEG reactivityBrain Injury, 2011
- Interobserver Reproducibility of Electroencephalogram Interpretation in Critically Ill ChildrenJournal Of Clinical Neurophysiology, 2011
- Predictors of neurologic outcome in hypothermia after cardiac arrestAnnals of Neurology, 2010
- Electroencephalogram for prognosis after cardiac arrestJournal of Critical Care, 2010
- Validity and Reliability of Quantitative ElectroencephalographyJournal of Neurotherapy, 2010
- The neuro-ICU patient and electroencephalography paroxysms: if and when to treatCurrent Opinion in Critical Care, 2010
- Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrestCritical Care, 2010
- Continuous Electroencephalogram Monitoring in the Intensive Care UnitAnesthesia & Analgesia, 2009
- Interobserver Agreement in the Interpretation of EEG Patterns in Critically Ill AdultsJournal Of Clinical Neurophysiology, 2008
- EEG reactivity in the prognosis of severe head injuryNeurology, 1995