The Churches of the Broumov region are well known for their unique baroque architecture, distinct shapes, sizes, and constitutes an integral part of the Czech cultural heritage. The St. Barbara’s Church that has been studied in this article, is in the Otovice village of Broumov. It was built in the year 1726 by Bavarian architects Christoph Dientzenhofer and Kilian Ignaz and is significant because of its religious, artistic and historic values. The main objective of this study is to evaluate the structural safety and stability of St. Barbara’s Church based on a probabilistic approach. A deterministic assessment of the structure is carried out and the results are assessed concerning the present site condition. Depending upon the observed damages, a condition for failure is defined for the structure. The uncertainties in the material parameters are considered and reliability analysis is performed to determine the reliability index, probability of failure and influence of different material parameters in the structural stability.