Modeling HPV early promoter regulation
- 1 August 2015
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE) in 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- Vol. 2015 (1094687X), 6493-6496
- https://doi.org/10.1109/embc.2015.7319880
Abstract
In high risk forms, human papillomaviruses (HPV) can either induce or promote cancerous lesions, especially cervical cancer which is considered the second most common cancer in the women worldwide. HPV life cycle is tightly linked to the infected cell differentiation program and its evolution is strictly joined to the switch between the early and the late viral polycistronic promoters.The aim of this study is to develop a novel mathematical model which collects and structures the available biologic knowledge on the early promoter regulation for HPV in episomal form. The model includes the main regulation by E2 viral protein as well as a novel discovered co-regulation function mediated by the viral E1 protein. Only by including both E2 and E1 regulatory effect the model is able to correctly predict the temporal behaviour of the early promoter switching off. A possible use of the model as in silico tool to evaluate new antiviral therapies is discussed.Keywords
This publication has 11 references indexed in Scilit:
- The case for transmissible antivirals to control population-wide infectious diseaseTrends in Biotechnology, 2014
- Mapping of HPV transcripts in four human cervical lesions using RNAseq suggests quantitative rearrangements during carcinogenic progressionVirology, 2014
- The Papillomavirus E2 proteinsVirology, 2013
- Regulation of human papillomavirus gene expression by splicing and polyadenylationNature Reviews Microbiology, 2013
- Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interactionVirology, 2011
- Analytical distributions for stochastic gene expressionProceedings of the National Academy of Sciences of the United States of America, 2008
- Papillomavirus genome structure, expression, and post-transcriptional regulationFrontiers in Bioscience-Landmark, 2006
- Nuclear export of the APC tumour suppressor controls β-catenin function in transcriptionThe EMBO Journal, 2003
- Human Papillomavirus Type 31b Infection of Human Keratinocytes and the Onset of Early TranscriptionJournal of Virology, 2002
- Transcriptional Activity among High and Low Risk Human Papillomavirus E2 Proteins Correlates with E2 DNA BindingOnline Journal of Public Health Informatics, 2002