Cd4+ T Cell Subsets during Virus Infection
Open Access
- 19 June 2000
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 191 (12), 2159-2170
- https://doi.org/10.1084/jem.191.12.2159
Abstract
To analyze the antiviral protective capacities of CD4+ T helper (Th) cell subsets, we used transgenic T cells expressing an I-Ab–restricted T cell receptor specific for an epitope of vesicular stomatitis virus glycoprotein (VSV-G). After polarization into Th1 or Th2 effectors and adoptive transfer into T cell–deficient recipients, protective capacities were assessed after infection with different types of viruses expressing the VSV-G. Both Th1 and Th2 CD4+ T cells could transfer protection against systemic VSV infection, by stimulating the production of neutralizing immunoglobulin G antibodies. However, only Th1 CD4+ T cells were able to mediate protection against infection with recombinant vaccinia virus expressing the VSV-G (Vacc-IND-G). Similarly, only Th1 CD4+ T cells were able to rapidly eradicate Vacc-IND-G from peripheral organs, to mediate delayed-type hypersensitivity responses against VSV-G and to protect against lethal intranasal infection with VSV. Protective capacity correlated with the ability of Th1 CD4+ T cells to rapidly migrate to peripheral inflammatory sites in vivo and to respond to inflammatory chemokines that were induced after virus infection of peripheral tissues. Therefore, the antiviral protective capacity of a given CD4+ T cell is governed by the effector cytokines it produces and by its migratory capability.Keywords
This publication has 61 references indexed in Scilit:
- Actin-based motility of vaccinia virusNature, 1995
- Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient miceNature, 1994
- Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigmCell, 1994
- Localization of T Helper Cell Epitopes in the Vesicular Stomatitis Virus: The Nucleoprotein Is Responsible for Serotype Cross-Reactive T HelpViral Immunology, 1994
- The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouseCellular Immunology, 1991
- Lymphokine Control of In Vivo Immunoglobulin Isotype SelectionAnnual Review of Immunology, 1990
- Impaired Generation of Anti‐Viral Cytotoxicity against Lymphocytic Choriomeningitis and Vaccinia Virus in Mice Treated with CD4‐Specific Monoclonal AntibodyScandinavian Journal of Immunology, 1989
- Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral diseaseEuropean Journal of Immunology, 1989
- TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional PropertiesAnnual Review of Immunology, 1989
- The Immune Response of the Mouse to Lymphocytic Choriomeningitis Virus. I. Circulating AntibodiesJournal of General Virology, 1979