Neural organization of spoken language revealed by lesion–symptom mapping
Open Access
- 16 April 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 6 (1), 1-9
- https://doi.org/10.1038/ncomms7762
Abstract
Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system—meaning versus form and recognition versus production—and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity with frontal cortex, respectively. These findings provide a novel synthesis of traditional and contemporary views of the cognitive and neural architecture of language processing, emphasizing dual routes for speech processing and convergence of white matter tracts for semantic control and/or integration.This publication has 69 references indexed in Scilit:
- Language-Selective and Domain-General Regions Lie Side by Side within Broca’s AreaCurrent Biology, 2012
- The cortical organization of lexical knowledge: A dual lexicon model of spoken language processingBrain and Language, 2012
- Conduction aphasia, sensory-motor integration, and phonological short-term memory – An aggregate analysis of lesion and fMRI dataBrain and Language, 2011
- The neurobiology of semantic memoryTrends in Cognitive Sciences, 2011
- Support for anterior temporal involvement in semantic error production in aphasia: New evidence from VLSMBrain and Language, 2011
- Reflections on mirror neurons and speech perceptionTrends in Cognitive Sciences, 2009
- The arcuate fasciculus and the disconnection theme in language and aphasia: History and current stateCortex, 2008
- Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantificationNeuroImage, 2008
- A case-series test of the interactive two-step model of lexical access: Predicting word repetition from picture namingJournal of Memory and Language, 2007
- Reproducibility of quantitative tractography methods applied to cerebral white matterNeuroImage, 2007