Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study
- 30 September 2010
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 19 (10), 2562-2569
- https://doi.org/10.1158/1055-9965.EPI-10-0447
Abstract
Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). Results: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). Conclusion: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. Impact: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements. Cancer Epidemiol Biomarkers Prev; 19(10); 2562-9. (C) 2010 AACR.This publication has 32 references indexed in Scilit:
- Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibilityNature Genetics, 2009
- Reproductive factors and hormone use and risk of adult gliomasCancer Causes & Control, 2008
- Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohortBritish Journal of Cancer, 2008
- Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC)Endocrine-Related Cancer, 2008
- Is There an Association Between Meningioma and Hormone Replacement Therapy?Journal of Clinical Oncology, 2008
- Risk of Brain Tumors Associated with Exposure to Exogenous Female Sex HormonesAmerican Journal of Epidemiology, 2006
- Hormonal and reproductive factors and risk of glioma: A prospective cohort studyInternational Journal of Cancer, 2005
- Reproductive and hormonal factors and risk of brain tumors in adult femalesInternational Journal of Cancer, 2005
- Reproductive factors and the risk of brain tumors: A population-based study in SwedenInternational Journal of Cancer, 1997
- Modulation of meningioma cell growth by sex steroid hormones in vitroJournal of Neurosurgery, 1985