Regulatory T cells in acute and chronic kidney diseases
- 1 May 2018
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 314 (5), F679-F698
- https://doi.org/10.1152/ajprenal.00236.2017
Abstract
The Foxp3-expressing CD4+ regulatory T cells (Tregs), which is a subset of the helper T-cells (Th), constitute one of the major mechanisms of peripheral tolerance. Tregs prevent abnormal activation of the immune system throughout the lifespan, thus protecting from autoimmune and inflammatory diseases. Recent studies have elucidated the role of Tregs beyond autoimmunity. Tregs play important functions in controlling not only innate and adaptive immune cell activation, but also regulate non-immune cell function during insults and injury. Inflammation contributes to a multitude of acute and chronic diseases affecting the kidneys. This review examines the role of Tregs in pathogenesis of renal inflammatory diseases and explores the approaches for enhancing Tregs for prevention and therapy of renal inflammation.Keywords
Funding Information
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1R01DK105833, 1R01DK104963, 1R21 DK112105)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (2R01AI116725)
- UVA AstraZeneca Research Alliance
- LaunchPad Diabetes Fund
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