Transcriptional regulation by hypoxia inducible factors
Top Cited Papers
- 7 October 2013
- journal article
- review article
- Published by Informa UK Limited in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 49 (1), 1-15
- https://doi.org/10.3109/10409238.2013.838205
Abstract
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.Keywords
This publication has 140 references indexed in Scilit:
- Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapyTrends in Pharmacological Sciences, 2012
- Hypoxia-Inducible Factors in Physiology and MedicineCell, 2012
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1Cell, 2011
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1Cell, 2011
- Hypoxia-Inducible Factors and the Response to Hypoxic StressMolecular Cell, 2010
- Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1αMolecular Cell, 2010
- c-Myc Regulates Transcriptional Pause ReleaseCell, 2010
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1αCell, 2010
- Hypoxia-Inducible Factors, Stem Cells, and CancerCell, 2007
- RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1αMolecular Cell, 2007