Interaction of Metal Ions with Caffeine and Theophylline: Stability and Structural Features
- 1 October 2003
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Biomolecular Structure and Dynamics
- Vol. 21 (2), 289-295
- https://doi.org/10.1080/07391102.2003.10506924
Abstract
The interactions of caffeine and theophylline with divalent cadmium, mercury, strontium and barium ions were studied in aqueous solution and physiological pH. Fourier transform infrared spectroscopy (FTIR) and absorption spectra were used to determine the cation binding mode and association constants. Spectroscopic results showed that Cd2+, Hg2+, Sr2+ and Ba2++ bind strongly to caffeine and theophylline. Direct and indirect (through metal hydration shell) interactions were observed for caffeine and theophylline with Cd2+, Hg2+, Sr2+ and Ba2+ through O6 and N9 (caffeine) and O6, N9 and N7 atoms (theophylline). The overall binding constants are: k(Cd-caffeine) = 1.24 × 105 M−1, k(Hg-caffeine) = 1.74 × 105 M−1, k(Sr- caffeine) = 3.3 × 104 M−1, k(Ba-caffeine) = 1.8 × 104 M−1, k(Cd-theophylline) = 5.75 × 105 M−1, k(Hg-theophylline) = 2.14 × 105 M−1, k(Sr-theophylline) = 4.6 × 104 M−1, k(Ba-theophylline) = 3 × 104 M−1 These k values are evidence for weak and strong cation interactions in these metal complexes.Keywords
This publication has 13 references indexed in Scilit:
- Interaction of Tl+3 with mononucleotides: metal ion binding and sugar conformationJournal of Molecular Structure, 2001
- Interaction of La(III) and Tb(III) ions with purine nucleotides: Evidence for metal chelation (N‐7‐M‐PO3) and the effect of macrochelate formation on the nucleotide sugar conformationPeptide Science, 1991
- Interaction of guanylic acid with the Mg(II), Ca(II), Sr(II), and Ba(II) ions in the crystalline solid and aqueous solution: Evidence for the ribose C2′‐endo/anti and C3′‐endo/anti conformational changesPeptide Science, 1991
- The interaction of cadmium and certain other metal ions with proteins and nucleic acidsToxicology, 1980
- Properties of graphical representations of multiple classes of binding sitesBiochemistry, 1971
- Interactions of Metal Ions with Polynucleotides and Related Compounds. VII. The Binding of Copper(II) to Nucleosides, Nucleotides, and Deoxyribonucleic Acids*Biochemistry, 1966
- INTERACTIONS OF METAL IONS WITH POLYNUCLEOTIDES AND RELATED COMPOUNDS, V. THE UNWINDING AND REWINDING OF DNA STRANDS UNDER THE INFLUENCE OF COPPER (II) IONSProceedings of the National Academy of Sciences of the United States of America, 1965
- The binding of magnesium to microsomal nucleoprotein and ribonucleic acidBiochimica et Biophysica Acta, 1960
- Molecular Structure of the Nucleic AcidsReviews of Modern Physics, 1959
- Absorption Spectra. VIII. The Infrared Spectra of Some Purines and Pyrimidines1,2Journal of the American Chemical Society, 1950