5‐HT1B Receptor Modulation of Prepulse Inhibition: Recent Findings in Wild‐type and 5‐HT1B Knockout Micea
- 1 December 1998
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 861 (1), 79-84
- https://doi.org/10.1111/j.1749-6632.1998.tb10176.x
Abstract
Sensorimotor gating of the startle reflex occurs when the presentation of a weak “prepulse” 30–500 msec prior to a startling stimulus inhibits the reflex, and is called prepulse inhibition (PPI). The study of PPI has recently been extended to mice to take advantage of recent advances in molecular genetics, because several neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, and schizotypal personality disorder are characterized by PPI deficits 1-3 . Studies in wild-type and 5-HT1B knockout mice suggest that activation of 5-HT1B receptors decreases PPI. The direct 5-HT1A/1B agonist RU24969 decreases PPI in wild-type but not 5-HT1B knockout mice. Likewise, the serotonin releasing compounds MDMA(+), MBDB(±), and alpha-ethyltryptamine (AET) have no effect on PPI in wild-type mice, but increase PPI in 5-HT1B knockout mice. As the direct 5-HT1A agonist 8-OH-DPAT increases PPI in mice, the unmasking of these effects may also contribute to the PPI-increasing effects of 5-HT releasers in 5-HT1B knockout mice.Keywords
This publication has 17 references indexed in Scilit:
- How Efficacious are 5-HT1B/D Receptor Ligands: an Answer from GTPγS Binding Studies with Stably Transfected C6-glial Cell LinesNeuropharmacology, 1997
- Serotonin, obsessive compulsive disorder and the basal gangliaInternational Review of Psychiatry, 1995
- Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B ReceptorScience, 1994
- Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in ratsNeuropharmacology, 1994
- Of mice and flies: commonalities among 5-HT receptorsTrends in Pharmacological Sciences, 1992
- Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificityBiochemical and Biophysical Research Communications, 1992
- The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implicationsJournal of Psychopharmacology, 1992
- Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brainTrends in Pharmacological Sciences, 1989
- Prestimulus Effects on Human Startle Reflex in Normals and SchizophrenicsPsychophysiology, 1978
- The More or Less Startling Effects of Weak PrestimulationPsychophysiology, 1975