Suppressive Effects of Britanin, a Sesquiterpene Compound Isolated from Inulae Flos, on Mast Cell-Mediated Inflammatory Responses
- 1 January 2014
- journal article
- Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine
- Vol. 42 (4), 935-947
- https://doi.org/10.1142/s0192415x14500591
Abstract
Mast cells are central players in immediate-type hypersensitvity and inflammatory responses. In the present study, the effects of britanin on the passive cutaneous anaphylaxis (PCA) reaction in mice and on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced production of pro-inflammatory cytokines in human mast cell line (HMC-1) were evaluated. The oral administration of britanin (10–20 mg/kg) decreased the mast cell-mediated PCA reaction in IgE-sensitized mice. In the activity and mechanism of britanin in vitro assay, britanin suppressed the gene expression and secretion of pro-inflammatory cytokines in a dose-dependent manner in HMC-1. In addition, britanin attenuated PMACI-induced activation of NF-κB as indicated by the inhibition of the degradation of IκBα, nuclear translocation of NF-κB, NF-κB/DNA binding activity assay, and blocked the phosphorylation of p38 MAP kinase, in a dose-dependent manner. We conclude that britanin may have potential as a treatment for allergic-inflammatory diseases.Keywords
This publication has 27 references indexed in Scilit:
- Chrysin suppresses mast cell-mediated allergic inflammation: Involvement of calcium, caspase-1 and nuclear factor-κBToxicology and Applied Pharmacology, 2011
- The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretionInternational Immunopharmacology, 2005
- MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefitsBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
- MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent AdvancesAnnual Review of Immunology, 2005
- Substance P induces TNF-α and IL-6 production through NFκB in peritoneal mast cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003
- Effects of fexofenadine and other antihistamines on components of the allergic response: Adhesion moleculesJournal of Allergy and Clinical Immunology, 2003
- Mechanisms of Antihistamines and Mast Cell Stabilizers in Ocular Allergic InflammationCurrent Drug Targets - Inflammation & Allergy, 2002
- Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritisArthritis & Rheumatism, 1995
- Cytokine production by mast cells and basophilsCurrent Opinion in Immunology, 1991
- SOME STUDIES ON THE RELEASE OF HISTAMINE FROM MAST CELLS STIMULATED WITH POLYLYSINEBritish Journal of Pharmacology, 1980