Chemotherapy for Breast Cancer During Pregnancy: An 18-Year Experience From Five London Teaching Hospitals
- 20 June 2005
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 23 (18), 4192-4197
- https://doi.org/10.1200/jco.2005.03.038
Abstract
Purpose The rare association between breast cancer and pregnancy means that few oncologists gain an expertise in this area. In particular, there are few published data concerning the use of chemotherapy for breast cancer during pregnancy. In this retrospective case series, we describe the experiences of five hospitals in London, United Kingdom, and how they manage this condition. Patients and Methods Retrospective searches were performed at five London hospitals in order to identify women who received chemotherapy for breast cancer while pregnant. Results Twenty-eight women were identified who had received chemotherapy for breast cancer during pregnancy. Twenty-four women received adjuvant or neoadjuvant chemotherapy for early breast cancer, and four women received palliative chemotherapy for metastatic disease. A total of 116 cycles of chemotherapy were administered during pregnancy. Sixteen women were treated with anthracycline-based chemotherapy and 12 received cyclophosphamide, methotrexate, and fluorouracil. All but one of the women were treated after the first trimester. One spontaneous abortion occurred in the woman treated during her first trimester; otherwise, there were no serious adverse consequences for the mothers or neonates. Conclusion These data provide evidence that in terms of peripartum complications and immediate fetal outcome, chemotherapy can be safely administered to women during the second and third trimesters of pregnancy.Keywords
This publication has 28 references indexed in Scilit:
- Breast carcinoma in pregnant womenCancer, 2003
- Possible Influence of Granulocyte Colony-Stimulating Factor and Recombinant Human Erythropoietin on Human Chorionic Gonadotropin Secretion during Chemotherapy for Choriocarcinoma: To the EditorGynecologic Oncology, 2001
- Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literatureUltrasound in Obstetrics & Gynecology, 2001
- Metastatic breast cancer in pregnancy: first case of chemotherapy with docetaxelEuropean Journal of Cancer Care, 2000
- Polychemotherapy for early breast cancer: an overview of the randomised trialsThe Lancet, 1998
- Vinorelbine in pregnancyEuropean Journal of Cancer, 1997
- Fetal marrow suppression after maternal chemotherapy for leukaemia.Archives of Disease in Childhood: Fetal & Neonatal, 1994
- Clinicopathologic Characteristics and Prognosis of Breast Cancer Patients Associated with Pregnancy and Lactation: Analysis of Case‐Control Study in JapanJapanese Journal of Cancer Research, 1992
- Gestational carcinoma of the female breastCurrent Problems in Cancer, 1983
- CYTOTOXIC DRUGS IN PREGNANCYBJOG: An International Journal of Obstetrics and Gynaecology, 1968