Natural SIV Hosts: Showing AIDS the Door
- 9 March 2012
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 335 (6073), 1188-1193
- https://doi.org/10.1126/science.1217550
Abstract
Lessons from SIV: HIV infection in humans is a chronic infection and, if left untreated, the majority of infected individuals will succumb to AIDS. Many species of African nonhuman primates are chronically infected with simian immunodeficiency virus (SIV); however, in the majority of these species, the animals remain healthy despite the presence of high viral loads. Chahroudi et al. (p. 1188 ) review the underlying immune mechanisms that help protect natural hosts from progressing to AIDS and how these responses differ from what is observed in HIV-infected humans and SIV-infected nonhuman primate species that develop AIDS.Keywords
This publication has 70 references indexed in Scilit:
- Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinNature, 2011
- Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expressionNature Medicine, 2011
- SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxNature, 2011
- Nonprogressive and Progressive Primate Immunodeficiency Lentivirus InfectionsImmunity, 2010
- Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 StrainsCell Host & Microbe, 2009
- Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hostsNature Medicine, 2009
- Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpzNature, 2009
- CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infectionNature Medicine, 2009
- Microbial translocation, the innate cytokine response, and HIV-1 disease progression in AfricaProceedings of the National Academy of Sciences of the United States of America, 2009
- Microbial translocation is a cause of systemic immune activation in chronic HIV infectionNature Medicine, 2006