Treatment options for recurrent giant cell tumors of bone
- 3 June 2008
- journal article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 135 (1), 149-158
- https://doi.org/10.1007/s00432-008-0427-x
Abstract
Although the recurrence rate of giant cell tumors of bone (GCTB) is relatively high exact data on treatment options for the recurrent cases is lacking. The possible surgical procedures range from repeated intralesional curettage to wide resection. Two hundred and fourteen patients with histologically certified GCTB have been treated at the authors department from 1980 to 2007. Sixty-seven patients with at least one local recurrence were included in this study. The mean follow-up was 77.3 months. The data was evaluated according the re-recurrence rate with regard to the surgical procedure for the recurrence. The mean time until the first local recurrence was 22.0 months; the mean number of recurrences per patient was 1.4. The recurrence occurred in 69.7% (46 out of 66 patients) within the first 2 years. If after intralesional procedures (curettage or intralesional resection) no adjunct was used the re-recurrence rate was 58.8% (10 out of 17 patients) and decreased to 21.7% (5 out of 23 patients) if a combination of all adjuncts (PMMA + burring) was used. The likelihood of re-recurrence was reduced by the factor 5.508 which was clearly significant (P = 0.016). In case of wide resection no re-recurrence occurred. Seven patients (10.5%) developed pulmonary metastases. Fourteen patients (20.9%) finally received an endoprosthesis; 12 due to tumor recurrence, 2 due to secondary arthritis. Recurrent GCTB can be treated by further curettage with additional burring and cementing with an acceptable re-recurrence rate of 21.7%. The rate of patients finally needing an endoprosthesis is 20.9%. Due to the high rate of pulmonary metastases recurrent GCTB may be considered as a severe disease.Keywords
This publication has 55 references indexed in Scilit:
- Extensive total spondylectomy for recurrent giant cell tumor in the thoracic spineJournal of Neurosurgery: Spine, 2007
- Comparison of the degenerative changes in weight-bearing joints following cementing or grafting techniques in giant cell tumour patients: medium-term resultsInternational Orthopaedics, 2006
- Histologically verified lung metastases in benign giant cell tumours—14 cases from a single institutionInternational Orthopaedics, 2006
- Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapyInternational Orthopaedics, 2006
- Treatment of local recurrences of giant cell tumour in long bones after curettage and cementingThe Journal of Bone and Joint Surgery. British volume, 2006
- Management of grade III giant cell tumors of bonesJournal of Surgical Oncology, 2005
- Surgical treatment of giant cell tumours of the thoracic and lumbar spine: report of nine patientsEuropean Spine Journal, 2001
- Reconstruction following en bloc resection of a giant cell tumor of the distal radius using a vascularized pedicle graft of the ulnaThe Journal of Hand Surgery, 1998
- Giant cell tumor of the distal radiusThe Journal of Hand Surgery, 1995
- Giant-Cell Tumor of Bone With Pulmonary MetastasesClinical Orthopaedics and Related Research, 1988