A New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction
Top Cited Papers
- 27 September 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (42), 12692-12693
- https://doi.org/10.1021/ja0373871
Abstract
A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87−94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.Keywords
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