Functional identification of an aggression locus in the mouse hypothalamus
Open Access
- 9 February 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 470 (7333), 221-226
- https://doi.org/10.1038/nature09736
Abstract
Electrical stimulation of certain hypothalamic regions in cats and rodents can elicit attack behaviour, but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their relationship to mating circuits have not been clear. Genetic methods for neural circuit manipulation in mice provide a potentially powerful approach to this problem, but brain-stimulation-evoked aggression has never been demonstrated in this species. Here we show that optogenetic, but not electrical, stimulation of neurons in the ventromedial hypothalamus, ventrolateral subdivision (VMHvl) causes male mice to attack both females and inanimate objects, as well as males. Pharmacogenetic silencing of VMHvl reversibly inhibits inter-male aggression. Immediate early gene analysis and single unit recordings from VMHvl during social interactions reveal overlapping but distinct neuronal subpopulations involved in fighting and mating. Neurons activated during attack are inhibited during mating, suggesting a potential neural substrate for competition between these opponent social behaviours.Keywords
This publication has 45 references indexed in Scilit:
- Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitryNature, 2010
- Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's DiseaseJournal of Neuroscience, 2009
- Optical Deconstruction of Parkinsonian Neural CircuitryScience, 2009
- Dissecting the brain's fear system reveals the hypothalamus is critical for responding in subordinate conspecific intrudersProceedings of the National Academy of Sciences of the United States of America, 2009
- Switching on and off fear by distinct neuronal circuitsNature, 2008
- Wired for Reproduction: Organization and Development of Sexually Dimorphic Circuits in the Mammalian ForebrainAnnual Review of Neuroscience, 2002
- Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systemsBrain Research Reviews, 2001
- Ethology and pharmacology of hypothalamic aggression in the ratNeuroscience & Biobehavioral Reviews, 1992
- A locked, non-rotating, completely embedded, moveable electrode for chronic brain stimulation studies in freely moving, fighting ratsPhysiology & Behavior, 1983
- The ventromedial hypothalamus and aggressive behaviour in ratsAggressive Behavior, 1977