Biological therapy and nail psoriasis
- 1 January 2007
- journal article
- review article
- Published by Hindawi Limited in Dermatologic Therapy
- Vol. 20 (1), 60-67
- https://doi.org/10.1111/j.1529-8019.2007.00112.x
Abstract
Nail psoriasis affects 50% of psoriasis patients and in many cases causes impairment of manual dexterity, pain, and psychologic stress. Despite the fact that about 80% of psoriatic arthritis patients have nail involvement, patients rarely receive treatment for nail disease. Because of great difficulty in drug delivery to site of action and significant toxicities of most conventional systemic therapies, treatment of nail psoriasis can be very challenging. Biological therapy for psoriasis and psoriatic arthritis is now widely used, and early evidence indicates it may have significant benefit for some patients with psoriatic nail disease. This article reviews the clinical manifestations of nail psoriasis and discusses how to use specific biologic therapies that may provide significant new treatment options for this challenging disease.Keywords
This publication has 41 references indexed in Scilit:
- Safety of Etanercept in PsoriasisDrug Safety, 2006
- Severe Exacerbation of Psoriatic Arthritis during Treatment with Efalizumab. A Case ReportPublished by Medical Journals Sweden AB ,2006
- Effective management of psoriasis symptom worsening during efalizumab therapy without discontinuing treatment: A case studyJournal of Dermatological Treatment, 2006
- Safety of Efalizumab in Patients with Moderate to Severe Chronic Plaque Psoriasis: Review of Clinical Data. Part IIJournal of Cutaneous Medicine and Surgery, 2005
- Modification of the nail psoriasis severity indexJournal of the American Academy of Dermatology, 2005
- Successful retreatment with infliximab in patients with prior severe infusion reactionsClinical Rheumatology, 2005
- An update on disorders of the nailsJournal of the American Academy of Dermatology, 2005
- Psoriatic Nails: A Prospective Clinical StudyJournal of Cutaneous Medicine and Surgery, 2003
- A prospective, clinical and radiological study of early psoriatic arthritis: an early synovitis clinic experienceRheumatology, 2003
- The impact of psoriasis on quality of lifeBritish Journal of Dermatology, 2001