Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
Top Cited Papers
Open Access
- 27 June 2016
- Vol. 21 (7), 844
- https://doi.org/10.3390/molecules21070844
Abstract
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.Funding Information
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
This publication has 278 references indexed in Scilit:
- Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cellsThe Journal of Nutritional Biochemistry, 2012
- TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in miceCell Research, 2011
- Roles of reactive oxygen and nitrogen species in painFree Radical Biology & Medicine, 2011
- The effects of hedonically acceptable red pepper doses on thermogenesis and appetitePhysiology & Behavior, 2011
- Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cordPain, 2009
- The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satietyEuropean Journal of Nutrition, 2009
- Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseasesThe International Journal of Biochemistry & Cell Biology, 2009
- The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neuronsPain, 2007
- Human gut microbes associated with obesityNature, 2006
- Prevalence of Overweight and Obesity in the United States, 1999-2004Published by American Medical Association (AMA) ,2006