Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice
Open Access
- 1 June 2009
- journal article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 10 (1), 43
- https://doi.org/10.1186/1465-9921-10-43
Abstract
The immune mechanisms associated with infection-induced disease exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an important role in recognition of double-stranded viral RNA, which leads to the production of various inflammatory mediators. Thus, an understanding of TLR3 activation should provide insight into the mechanisms underlying virus-induced exacerbations of pulmonary diseases.Keywords
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