Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients
Open Access
- 31 October 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 122 (18), 3206-3209
- https://doi.org/10.1182/blood-2013-06-507962
Abstract
Key Points We found the defective ALDH2 variant is associated with accelerated progression of BMF in Japanese FA patients. The data support the view that aldehydes are an important source of genotoxicity in the human hematopoietic system.Keywords
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