Lesions of endodontic origin and risk of coronary heart disease.
Open Access
- 1 November 2006
- journal article
- other
- Published by SAGE Publications in Journal of Dental Research
- Vol. 85 (11), 996-1000
- https://doi.org/10.1177/154405910608501104
Abstract
A paucity of epidemiologic research exists regarding systemic health consequences of endodontic disease. This study evaluated whether incident radiographically evident lesions of endodontic origin were related to development of coronary heart disease (CHD) among 708 male participants in the VA Dental Longitudinal Study. At baseline and every three years for up to 32 years, participants (who were not VA patients) received complete medical and dental examinations, including full-mouth radiographs. Cox regression models estimated the relationship between incident lesions of endodontic origin and time to CHD diagnosis. Among those ≤ 40 years old, incident lesions of endodontic origin were significantly associated with time to CHD diagnosis (p < 0.05), after adjustment for covariates of interest, with hazard ratios decreasing as age increased. Among those > 40 years old, no statistically significant association was observed. These findings are consistent with research that suggests relationships between chronic periodontal inflammation and the development of CHD, especially among younger men.Keywords
This publication has 29 references indexed in Scilit:
- Epidemiologic issues in studies of association between apical periodontitis and systemic healthEndodontic Topics, 2004
- Periodontal Disease as a Risk Factor for Ischemic StrokeStroke, 2004
- Associations Between Periodontal Disease and Risk for Nosocomial Bacterial Pneumonia and Chronic Obstructive Pulmonary Disease. A Systematic ReviewAnnals of Periodontology, 2003
- Periodontal Disease and Preterm Birth: Results of a Pilot Intervention StudyThe Journal of Periodontology, 2003
- Periapical health and treatment quality assessment of root-filled teeth in two Canadian populationsInternational Endodontic Journal, 2003
- Levels of Interleukin‐1β, ‐8, and ‐10 and RANTES in Gingival Crevicular Fluid and Cell Populations in Adult Periodontitis Patients and the Effect of Periodontal TreatmentThe Journal of Periodontology, 2000
- Periapical status of endodontically treated teeth in relation to the technical quality of the root filling and the coronal restorationInternational Endodontic Journal, 1995
- Influence of surgical treatment of periapical lesions on serum and blood levels of inflammatory mediatorsInternational Endodontic Journal, 1992
- Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatmentOral Microbiology and Immunology, 1988
- A Coefficient of Agreement for Nominal ScalesEducational and Psychological Measurement, 1960