Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity against Phytophthora infestans
Open Access
- 1 March 2008
- journal article
- Published by Oxford University Press (OUP) in Journal of Applied Microbiology
- Vol. 104 (3), 692-698
- https://doi.org/10.1111/j.1365-2672.2007.03581.x
Abstract
To isolate and identify antioomycete substances from Fusarium oxysporum EF119 against Phytophthora infestans and to investigate their antimicrobial activities against various plant pathogenic bacteria, oomycetes and true fungi. Two antioomycete substances were isolated from liquid cultures of F. oxysporum EF119, which shows a potent disease control efficacy against tomato late blight caused by P. infestans. They were identified as bikaverin and fusaric acid by mass and nuclear magnetic resonance spectral analyses. They inhibited the mycelial growth of plant pathogenic oomycetes and fungi. Fusaric acid also effectively suppressed the cell growth of various plant pathogenic bacteria, but bikaverin was virtually inactive. Treatment with bikaverin at 300 microg ml(-1) suppressed the development of tomato late blight by 71%. Fusaric acid provided effective control against tomato late blight and wheat leaf rust over 67% at concentrations more than 100 microg ml(-1). Both bikaverin and fusaric acid showed in vitro and in vivo antioomycete activity against P. infestans. Fusarium oxysporum EF119 producing both bikaverin and fusaric acid may be used as a biocontrol agent against tomato late blight caused by P. infestans.Keywords
This publication has 20 references indexed in Scilit:
- Some fungal endophytes from vegetable crops and their anti-oomycete activities against tomato late blightLetters in Applied Microbiology, 2007
- Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildewPest Management Science, 2004
- United States Department of Agriculture—Agricultural Research Service studies on polyketide toxins of Fusarium oxysporum f sp vasinfectum: potential targets for disease controlPest Management Science, 2003
- Ability of Nonpathogenic Fusarium oxysporum Strain Fo47 To Induce Resistance against Pythium ultimum Infection in CucumberApplied and Environmental Microbiology, 2002
- Cytological Analysis of Defense-Related Mechanisms Induced in Pea Root Tissues in Response to Colonization by Nonpathogenic Fusarium oxysporum Fo47Phytopathology®, 2001
- THE EVOLUTIONARY BIOLOGY OFFUSARIUM OXYSPORUMAnnual Review of Phytopathology, 1997
- RESISTANCE TO PHENYLAMIDE FUNGICIDES:A Case Study with Phytophthora infestans Involving Mating Type and Race StructureAnnual Review of Phytopathology, 1996
- Fusoxysporone - a new type of diterpene from fusarium oxysporumTetrahedron, 1992
- Competition for Carbon in Soil and Rhizosphere, a Mechanism Involved in Biological Control of Fusarium WiltsPublished by Springer Science and Business Media LLC ,1992
- FUSARIC ACID, A HYPOTENSIVE AGENT PRODUCED BY FUNGIThe Journal of Antibiotics, 1969