FGF-2 Stimulates Periodontal Regeneration
- 8 November 2010
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 90 (1), 35-40
- https://doi.org/10.1177/0022034510384616
Abstract
The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 µL of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.Keywords
This publication has 18 references indexed in Scilit:
- The use of biologic mediators and tissue engineering in dentistryPeriodontology 2000, 2009
- Periodontal Tissue Regeneration Using Fibroblast Growth Factor -2: Randomized Controlled Phase II Clinical TrialPLOS ONE, 2008
- Platelet‐Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled TrialThe Journal of Periodontology, 2005
- Novel Isolation of Alkaline Phosphatase‐Positive Subpopulation from Periodontal Ligament FibroblastsThe Journal of Periodontology, 2003
- Microorganisms as risk indicators for periodontal diseasePeriodontology 2000, 2003
- Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogsJournal of Periodontal Research, 2003
- Phenotypic comparison of periodontal ligament cells in vivo and in vitroJournal of Periodontal Research, 2001
- Guided tissue regeneration in conjunction with hydroxyapatite-collagen grafts for intrabony defects. A clinical and radiological evaluationJournal of Clinical Periodontology, 1997
- Histologic Evaluation of New Attachment in Human Intrabony Defects: A Literature ReviewThe Journal of Periodontology, 1982
- Osseous repair of an infrabony pocket without new attachment of connective tissueJournal of Clinical Periodontology, 1976