Single‐Dose Kinetics of Intravenous Vancomycin
- 1 April 1980
- journal article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 20 (4), 197-201
- https://doi.org/10.1002/j.1552-4604.1980.tb01696.x
Abstract
The pharmacokinetic properties of intravenously administered vancomycin were studied in four healthy volunteers. Reversible adverse effects (flushing, tachycardia, pruritus) occurred in two subjects who received high-dose rapid intravenous infusions. Distribution of vancomycin proceeded as a biphasic process in all four subjects. The initial distribution half-life (t1/2 alpha) was less than 8 minutes in all cases, with intermediate half-lives (t1/2 pi) varying from 0.43 to 1.48 hour and elimination half-lives (t1/2 beta) varying from 4.7 to 11.2 hours. Vancomycin clearance was less than creatinine clearance, probably because of serum protein binding, which was determined to be 55 per cent.Keywords
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