Introduction of the CKD-EPI equation to estimate glomerular filtration rate in a Caucasian population
- 16 February 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation
- Vol. 26 (10), 3176-3181
- https://doi.org/10.1093/ndt/gfr003
Abstract
Chronic kidney disease (CKD) is defined as the presence of kidney damage, albuminuria or a reduction in glomerular filtration rate (GFR). A GFR <60 mL/min/1.73 m(2) alone is sufficient to diagnose CKD Stages III-V. Recently, the new chronic kidney disease epidemiology collaboration (CKD-EPI) equation was introduced. It has been suggested to result in higher estimated glomerular filtration rates (eGFRs) than the Modification of Diet in Renal Disease (MDRD(4)) formula. Here, we assess consequences of introducing the CKD-EPI equation in a West European Caucasian population. Data were obtained from 6097 Caucasian participants of the Nijmegen Biomedical Study (2823 males and 3274 females). Serum creatinine values were determined using the Jaffe method, calibrated against mass spectrometry and were used to calculate eGFR(MDRD4) and eGFR(CKD-EPI). Demographic data, health status and information on medication use for all participants was obtained with a postal questionnaire. The introduction of the CKD-EPI equation changed the curve of eGFR by age, with higher values in the younger age groups and a steeper decline of eGFR with ageing. As a consequence, younger people were more often classified to a higher GFR stage and older people, especially males, to a lower GFR stage. In comparison with the MDRD(4) formula, the CKD-EPI equation leads to higher estimates of GFR in young people and lower estimates in the elderly. On a population level, this may lead to higher estimates of kidney function. However, in routine clinical practice where the population is predominantly elderly, the opposite may be true. The introduction of eGFR(CKD-EPI) necessitates reconsidering the definition of CKD. We suggest introducing age-dependent threshold values and/or the use of urinary albumin excretion to improve risk stratification.Keywords
This publication has 18 references indexed in Scilit:
- Influence of Age and Measure of eGFR on the Association between Renal Function and Cardiovascular EventsClinical Journal of the American Society of Nephrology, 2010
- Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisThe Lancet, 2010
- Risk Implications of the New CKD Epidemiology Collaboration (CKD-EPI) Equation Compared With the MDRD Study Equation for Estimated GFR: The Atherosclerosis Risk in Communities (ARIC) StudyAmerican Journal of Kidney Diseases, 2010
- Comparison of the Prevalence and Mortality Risk of CKD in Australia Using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR Estimating Equations: The AusDiab (Australian Diabetes, Obesity and Lifestyle) StudyAmerican Journal of Kidney Diseases, 2010
- Rapid Decline of Kidney Function Increases Cardiovascular Risk in the ElderlyJournal of the American Society of Nephrology, 2009
- CKD and Mortality Risk in Older People: A Community-Based Population Study in the United KingdomAmerican Journal of Kidney Diseases, 2009
- Age- and gender-specific reference values of estimated glomerular filtration rate in a Caucasian population: Results of the Nijmegen Biomedical StudyKidney International, 2008
- Chronic kidney disease definition and classification: the quest for refinementsKidney International, 2007
- Thyroid Function and Prevalence of Anti-Thyroperoxidase Antibodies in a Population with Borderline Sufficient Iodine Intake: Influences of Age and SexClinical Chemistry, 2006
- Smoothing reference centile curves: The lms method and penalized likelihoodStatistics in Medicine, 1992