Antiangiogenesis activity test of tin leaf (Ficus carica L.) on the number of blood vessels and VEGF expression of chorioallantoic membrane of embryonated chicken eggs
- 1 October 2018
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Oncology Pharmacy
- Vol. 1 (4), e00007
- https://doi.org/10.1097/op9.0000000000000007
Abstract
This research has been conducted on the antiangiogenesis activity test of the tin leaf (Ficus carica L.) on the number of blood vessels and vascular endothelial growth factor (VEGF) expression of chorioallantoic membrane (CAM) of embryonated chicken eggs. The general objective of this study is the use of natural products from the F. carica L. as chemopreventive in cancer through the mechanism of inhibition of angiogenesis. Inhibition of angiogenesis, supply of nutrients and oxygen to cancer cells will also be inhibited, so that indirectly cancer cells will be stunted. This study used 25 embryonated chicken eggs that divided into 5 treatments and each treatment has 5 repetitions. This treatment includes placebo negative controls, celecoxib-positive controls, and 3 treatment groups were given a water extract of F. carica L. which was divided into several doses of 75, 90, and 110 μg. The result found a significant difference (P PKeywords
This publication has 10 references indexed in Scilit:
- Vascular endothelial growth factor signaling requires glycine to promote angiogenesisScientific Reports, 2017
- Methanolic Extract ofFicus caricaLinn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of InflammationEvidence-Based Complementary and Alternative Medicine, 2015
- Chick Chorioallantoic Membrane (CAM) Assay as an In Vivo Model to Study the Effect of Newly Identified Molecules on Ovarian Cancer Invasion and MetastasisInternational Journal of Molecular Sciences, 2012
- Antioxidant and Immunity Activity of Water Extract and Crude Polysaccharide from Ficus carica L. FruitPlant Foods for Human Nutrition, 2009
- Inflammatory processes in preterm and term parturitionJournal of Reproductive Immunology, 2008
- Clinical translation of angiogenesis inhibitorsNature Reviews Cancer, 2002
- Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factorsGene Therapy, 2002
- Angiogenesis: regulators and clinical applicationsBiochemical Pharmacology, 2001
- FGF-1: a human growth factor in the induction of neoangiogenesisExpert Opinion on Investigational Drugs, 1998
- New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.Journal of Vascular Research, 1997