The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database
- 21 May 2010
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 120 (6), 1233-1245
- https://doi.org/10.1002/lary.20901
Abstract
Objectives/Hypothesis: To develop a national database of cases of juvenile onset recurrent respiratory papillomatosis (JoRRP) in Canada, to calculate trends in incidence and prevalence of JoRRP from January 1994 to December 2007 at the national and regional level, and to mathematically model the natural history of JoRRP. Study Design: Retrospective, multicenter study. Methods: Patient demographics, clinical presentation, human papillomavirus status, method and timing of treatment, and indicators of disease severity were captured with a standardized case report form. Operative records were retrospectively scored using the Derkay‐Coltrera staging system for each operative intervention. Trends in incidence and prevalence of JoRRP from 1994 to 2007 were calculated at a national and regional level using national population census data. A multivariable mixed effects linear model was used to explore the effect of surgery‐specific variables on the intersurgical interval. Nonlinear least‐squares regression was used to model the natural history of JoRRP. Results: Development of a national database of children with JoRRP identified 243 cases who underwent 3,021 surgical procedures. The national incidence of JoRRP from 1994 to 2007 was 0.24 per 100,000 children aged 14 years and younger. The prevalence was 1.11 per 100,000 children. The natural history of JoRRP followed a nonlinear time course with 64% of cases having a decreasing annual rate of surgery over time. Conclusions: A Canadian national database of children with JoRRP was successfully developed. Modeling of the natural history of JoRRP may have important clinical and research implications. Laryngoscope, 2010Keywords
This publication has 34 references indexed in Scilit:
- Twenty-Year Trends in the Incidence and Prevalence of Diagnosed Anogenital Warts in CanadaSexually Transmitted Diseases, 2009
- Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patientsActa Oto-Laryngologica, 2009
- Epidemiology and costs associated with genital warts in CanadaSexually Transmitted Infections, 2008
- The economic burden of noncervical human papillomavirus disease in the United StatesAmerican Journal of Obstetrics and Gynecology, 2008
- Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory PapillomatosisPLOS ONE, 2008
- Time Course of Juvenile Onset Recurrent Respiratory Papillomatosis Caused by Human PapillomavirusThe Pediatric Infectious Disease Journal, 2008
- Tracheal, Bronchial, and Pulmonary Papillomatosis in ChildrenThe Laryngoscope, 2005
- Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric PopulationThe Laryngoscope, 2004
- A comparison of risk factors in juvenile‐onset and adult‐onset recurrent respiratory papillomatosisThe Laryngoscope, 1992
- Juvenile laryngeal papillomatosis. An epidemiological study from the Copenhagen regionActa Oto-Laryngologica, 1988