New TEM Variant (TEM-92) Produced by Proteus mirabilis and Providencia stuartii Isolates
Open Access
- 1 April 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (4), 1278-1280
- https://doi.org/10.1128/aac.45.4.1278-1280.2001
Abstract
The sequences of the bla TEM genes encoding TEM-92 in Proteus mirabilis and Providencia stuartii isolates were determined and were found to be identical. Except for positions 218 (Lys-6) and 512 (Lys-104), the nucleotide sequence of bla TEM-92 was identical to that of bla TEM-20 , including the sequence of the promoter region harboring a 135-bp deletion combined with a G-162→T substitution. The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6→Lys) in the peptide signal.Keywords
This publication has 18 references indexed in Scilit:
- A 1998 Survey of Extended-Spectrum β-Lactamases in Enterobacteriaceae in FranceAntimicrobial Agents and Chemotherapy, 2000
- TEM-72, a New Extended-Spectrum β-Lactamase Detected in Proteus mirabilis and Morganella morganii in ItalyAntimicrobial Agents and Chemotherapy, 2000
- Clinical relevance of Proteus mirabilis in hospital patients: a two year surveyJournal of Antimicrobial Chemotherapy, 2000
- Molecular Diversity and Evolution of bla TEM Genes Encoding β-Lactamases Resistant to Clavulanic Acid in Clinical E. coliJournal of Molecular Evolution, 1997
- Detection of extended-spectrum plasmid-mediated β-lactamases by disk diffusionClinical Microbiology & Infection, 1996
- Survey of prevalence of extended spectrum β-lactamases among EnterobacteriaceaeJournal of Antimicrobial Chemotherapy, 1996
- Convergent evolution of TEM-26, a β-lactamase with extended-spectrum activityJournal of Antimicrobial Chemotherapy, 1994
- A standard numbering scheme for the class A β-lactamasesBiochemical Journal, 1991
- Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel β-lactamaseJournal of Antimicrobial Chemotherapy, 1987
- Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.Proceedings of the National Academy of Sciences of the United States of America, 1978