A Stable Sparse Fear Memory Trace in Human Amygdala
Open Access
- 22 June 2011
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 31 (25), 9383-9389
- https://doi.org/10.1523/jneurosci.1524-11.2011
Abstract
Pavlovian fear conditioning is highly conserved across species, providing a powerful model of aversive learning. In rodents, fear memory is stored and reactivated under the influence of the amygdala. There is no evidence for an equivalent mechanism in primates, and an opposite mechanism is proposed whereby primate amygdala contributes only to an initial phase of aversive learning, subsequently ceding fear memory to extra-amygdalar regions. Here, we reexamine this question by exploiting human high-resolution functional magnetic resonance imaging in conjunction with multivariate methods. By assuming a sparse neural coding, we show it is possible, at an individual subject level, to discriminate responses to conditioned (CS+ and CS−) stimuli in both basolateral and centro-cortical amygdala nuclei. The strength of this discrimination increased over time and was tightly coupled to the behavioral expression of fear, consistent with an expression of a stable fear memory trace. These data highlight that the human basolateral and centro-cortical amygdala support initial learning as well more enduring fear memory storage. A sparse neuronal representation for fear, here revealed by multivariate pattern classification, resolves why an enduring memory trace has proven elusive in previous human studies.This publication has 68 references indexed in Scilit:
- The impact of physiological noise correction on fMRI at 7TNeuroImage, 2011
- Dynamic causal modelling of anticipatory skin conductance responsesBiological Psychology, 2010
- Modelling event-related skin conductance responsesInternational Journal of Psychophysiology, 2010
- Neural substrates of explicit and implicit fear memoryNeuroImage, 2009
- The Nonhuman Primate Amygdala Is Necessary for the Acquisition but not the Retention of Fear-Potentiated StartleBiological Psychiatry, 2009
- Neural Circuitry Underlying the Regulation of Conditioned Fear and Its Relation to ExtinctionNeuron, 2008
- A method for improving the performance of gradient systems for diffusion‐weighted MRIMagnetic Resonance in Medicine, 2007
- Optimized EPI for fMRI studies of the orbitofrontal cortex: compensation of susceptibility-induced gradients in the readout directionMagnetic Resonance Materials in Physics, Biology and Medicine, 2007
- Beyond mind-reading: multi-voxel pattern analysis of fMRI dataTrends in Cognitive Sciences, 2006
- Image Distortion Correction in fMRI: A Quantitative EvaluationNeuroImage, 2002